Aims: This study will provide insight into the efficacy, feasibility, applicability, and affordability of delivering tobacco cessation interventions through health care professionals at HIV treatment centers in two countries with different tobacco use patterns, policy environments, and health care resources and provide needed information to providers and policymakers looking for cost-effective tobacco cessation interventions.

Sample size: 800 adult PLWH who use tobacco will be recruited by health care professionals at HIV treatment centers where they are receiving care.

Population: Adults (18+) in Uganda and Zambia who are living with HIV, use tobacco every day, and are receiving continuous HIV care from a treatment facility.

Recruitment: 800 PLWH who use tobacco will be recruited from HIV treatment centers in two districts in Uganda and Zambia each and randomized to one of the following four study arms (described in more detail below): (1) Standard of Care (SOC); (2) SOC + NRT; (3) SOC + SMS; and (4) SOC + NRT + SMS.

Data analysis: Multilevel logistic regression analysis will be used to assess differences in rates of tobacco use cessation between the study arms, and identification of the predictors of tobacco use cessation.

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