Tobacco Cessation for People Living with HIV
The Quit4Life+ study is the first randomized control trial (RCT) to test the efficacy of a tailored short message service (SMS) based tobacco use cessation intervention on prolonged tobacco use abstinence at 6 months post program initiation in comparison to the standard of care (brief advice to quit) and nicotine replacement therapy (nicotine patches) among people living with HIV in Uganda and Zambia.
Quit4Life+ is a partnership between the Center for Tobacco Control in Africa at the Makerere University School of Public Health, University of Zambia, University of Maryland School of Public Health, the Keck School of Medicine of USC, and the RAND Corporation; with technical support from the World Health Organization. The study is funded by the National Cancer Institute (NCI) under Project Number 7U01CA261624-05 through NCI's funding initiative to reduce tobacco use among people living with HIV in low- and middle-income countries.
About
Sites
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Uganda sites:
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Arua RRH
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Adumi HCIV
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Omugo HCIV
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River Oli HCIV
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Moroto RRH
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Kosiroi HCIII
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Nadunget HCIII/IV
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Nakaperimen HCII
Zambia sites:
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Mongu Provincial Hospital
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Kaoma District Hospital
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Senanga District Hospital
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Sesheke General Hospital
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Chipata Provincial Hospital
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Katete General Hospital
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Petauke District Hospital
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Lundazi General Hospital
Study sites were chosen for being accessible, having high tobacco use among PLWH, willing staff to take part in the study, support from the local stakeholders, and strong telecom coverages.
Meet the Study Team
Timeline
2022
Study Preparation and Formative Research
January
August
Launch meeting
Formative research phase and SMS message adaptation
2023
Formative Research and Study Launch
March
June
July
July
August
September
2024
Society for Research on Nicotine and Tobacco presentation
Training of trainers workshop, Livingston, Zambia
Investigator meeting, Entebbe, Uganda
Health care worker training in Uganda
Health care worker training in Zambia, Stigma supplement study funded
Study launch: Participant recruitment and enrollment initiated
Trial Implementation
January
August
September
November
December
2025
Stigma supplement study data collection initiated
Implementation science supplemental study funded
Implementation science health systems assessments
African Conference on Tobacco Control and Development presentation
Association of Pacific Rim Universities presentation
Trial Implementation
April
June
July-August
September
2026
Consortium of Universities of Global Health Conference presentation
World Conference on Tobacco Control presentation
Online implementation science training workshops
In person implementation science training hosted in Uganda
Analysis
March
April
July
Participant follow-ups completed
Consortium of Universities of Global Health Conference presention
Data analysis and publications planning workshop